PNAS/Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins [Biochemistry]
#16196 [ F. Donelson Smith, Mitchell H. ] 2018-12-04 09:11:23 hit: 6(#f9fff9)
LINK INFOa href="http://www.pnas.org/content/115/49/E11465.short?rss=1"
DOI: 10.1073/pnas.1816614115, A-kinase anchoring proteins (AKAPs) shape second-messenger signaling responses by constraining protein kinase A (PKA) at precise intracellular locations. A defining feature of AKAPs is a helical region that binds to regulatory subunits (RII) of PKA. Mining patient-derived databases has identified 42 nonsynonymous SNPs in the PKA-anchoring helices of five AKAPs....