PNAS/Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins [Biochemistry]

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#16196 [ F. Donelson Smith, Mitchell H. ] hit: 6(#f9fff9)


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  DOI: 10.1073/pnas.1816614115
, A-kinase anchoring proteins (AKAPs) shape second-messenger signaling responses by constraining protein kinase A (PKA) at precise intracellular locations. A defining feature of AKAPs is a helical region that binds to regulatory subunits (RII) of PKA. Mining patient-derived databases has identified 42 nonsynonymous SNPs in the PKA-anchoring helices of five AKAPs....