PNAS/Multiple prebiotic metals mediate translation [Earth, Atmospheric, and Planetary Sciences]

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#16191 [ Marcus S. Bray, Timothy K. Len ] hit: 7(#f8fff8)


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  DOI: 10.1073/pnas.1803636115
, Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life’s oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a functional ancestral state. First, SHAPE (selective 2′-hydroxyl acylation analyzed by primer...