PNAS/Multiple prebiotic metals mediate translation [Earth, Atmospheric, and Planetary Sciences]
#16191 [ Marcus S. Bray, Timothy K. Len ] 2018-11-27 10:26:27 hit: 7(#f8fff8)
LINK INFOa href="http://www.pnas.org/content/115/48/12164.short?rss=1"
DOI: 10.1073/pnas.1803636115, Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life’s oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a functional ancestral state. First, SHAPE (selective 2′-hydroxyl acylation analyzed by primer...