PNAS/KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway [Biochemistry]

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#16182 [ Hyunkyung Kim, Dongha Kim, Seo ] hit: 7(#f8fff8)


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  DOI: 10.1073/pnas.1805662115
, Janus tyrosine kinase 2 (JAK2)−signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2−STAT3 signaling pathway is frequently associated with human malignancies. Here, we provide evidence that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme...