PNAS/KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway [Biochemistry]
#16182 [ Hyunkyung Kim, Dongha Kim, Seo ] 2018-11-13 12:16:16 hit: 7(#f8fff8)
LINK INFOa href="http://www.pnas.org/content/115/46/11766.short?rss=1"
DOI: 10.1073/pnas.1805662115, Janus tyrosine kinase 2 (JAK2)−signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2−STAT3 signaling pathway is frequently associated with human malignancies. Here, we provide evidence that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme...