PNAS/Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel [Biochemistry]
#16177 [ Kaiqian Wang, Christian Holt, ] 2018-11-06 10:41:44 hit: 7(#f8fff8)
LINK INFOa href="http://www.pnas.org/content/115/45/E10556.short?rss=1"
DOI: 10.1073/pnas.1808733115, Calmodulin (CaM) represents one of the most conserved proteins among eukaryotes and is known to bind and modulate more than a 100 targets. Recently, several disease-associated mutations have been identified in the CALM genes that are causative of severe cardiac arrhythmia syndromes. Although several mutations have been shown to affect...