PNAS/Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel [Biochemistry]

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#16177 [ Kaiqian Wang, Christian Holt, ] hit: 7(#f8fff8)


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  DOI: 10.1073/pnas.1808733115
, Calmodulin (CaM) represents one of the most conserved proteins among eukaryotes and is known to bind and modulate more than a 100 targets. Recently, several disease-associated mutations have been identified in the CALM genes that are causative of severe cardiac arrhythmia syndromes. Although several mutations have been shown to affect...