PNAS/Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis [Biochemistry]

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#16175 [ Yue Zhang, Wan-Hong Wen, Jin-Y ] hit: 8(#f7fff7)


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  DOI: 10.1073/pnas.1800502115
, Understanding how antibiotic-producing bacteria deal with highly reactive chemicals will ultimately guide therapeutic strategies to combat the increasing clinical resistance crisis. Here, we uncovered a distinctive self-defense strategy featured by a secreted oxidoreductase NapU to perform extracellularly oxidative activation and conditionally overoxidative inactivation of a matured prodrug in naphthyridinomycin (NDM)...