PNAS/Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis [Biochemistry]
#16175 [ Yue Zhang, Wan-Hong Wen, Jin-Y ] 2018-10-30 09:46:28 hit: 8(#f7fff7)
LINK INFOa href="http://www.pnas.org/content/115/44/11232.short?rss=1"
DOI: 10.1073/pnas.1800502115, Understanding how antibiotic-producing bacteria deal with highly reactive chemicals will ultimately guide therapeutic strategies to combat the increasing clinical resistance crisis. Here, we uncovered a distinctive self-defense strategy featured by a secreted oxidoreductase NapU to perform extracellularly oxidative activation and conditionally overoxidative inactivation of a matured prodrug in naphthyridinomycin (NDM)...