PNAS/Mechanism of tRNA-mediated +1 ribosomal frameshifting [Biochemistry]

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#16174 [ Samuel Hong, S. Sunita, Tatsuy ] hit: 8(#f7fff7)

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a href="http://www.pnas.org/content/115/44/11226.short?rss=1"
  DOI: 10.1073/pnas.1809319115
, Accurate translation of the genetic code is critical to ensure expression of proteins with correct amino acid sequences. Certain tRNAs can cause a shift out of frame (i.e., frameshifting) due to imbalances in tRNA concentrations, lack of tRNA modifications or insertions or deletions in tRNAs (called frameshift suppressors). Here, we...

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