PNAS/Molecular mechanism of activation of the immunoregulatory amidase NAAA [Biochemistry]
#16169 [ Alexei Gorelik, Ahmad Gebai, K ] 2018-10-23 11:16:58 hit: 8(#f7fff7)
LINK INFOa href="http://www.pnas.org/content/115/43/E10032.short?rss=1"
DOI: 10.1073/pnas.1811759115, Palmitoylethanolamide is a bioactive lipid that strongly alleviates pain and inflammation in animal models and in humans. Its signaling activity is terminated through degradation by N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase expressed at high levels in immune cells. Pharmacological inhibitors of NAAA activity exert profound analgesic and antiinflammatory effects...