PNAS/Molecular mechanism of activation of the immunoregulatory amidase NAAA [Biochemistry]

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#16169 [ Alexei Gorelik, Ahmad Gebai, K ] hit: 8(#f7fff7)


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  DOI: 10.1073/pnas.1811759115
, Palmitoylethanolamide is a bioactive lipid that strongly alleviates pain and inflammation in animal models and in humans. Its signaling activity is terminated through degradation by N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase expressed at high levels in immune cells. Pharmacological inhibitors of NAAA activity exert profound analgesic and antiinflammatory effects...