PNAS/Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition [Biochemistry]
#16099 [ Lorena Saelices, Kevin Chung, ] 2018-07-17 09:06:11 hit: 2(#fdfffd)
LINK INFOa href="http://www.pnas.org/content/115/29/E6741.short?rss=1"
DOI: 10.1073/pnas.1805131115, Each of the 30 human amyloid diseases is associated with the aggregation of a particular precursor protein into amyloid fibrils. In transthyretin amyloidosis (ATTR), mutant or wild-type forms of the serum carrier protein transthyretin (TTR), synthesized and secreted by the liver, convert to amyloid fibrils deposited in the heart and...