PNAS/Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition [Biochemistry]

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#16099 [ Lorena Saelices, Kevin Chung, ] hit: 2(#fdfffd)


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  DOI: 10.1073/pnas.1805131115
, Each of the 30 human amyloid diseases is associated with the aggregation of a particular precursor protein into amyloid fibrils. In transthyretin amyloidosis (ATTR), mutant or wild-type forms of the serum carrier protein transthyretin (TTR), synthesized and secreted by the liver, convert to amyloid fibrils deposited in the heart and...