PNAS/Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase [Biochemistry]

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#16093 [ Russell D. Lewis, Marc Garcia& ] hit: 2(#fdfffd)


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  DOI: 10.1073/pnas.1807027115
, Recently, heme proteins have been discovered and engineered by directed evolution to catalyze chemical transformations that are biochemically unprecedented. Many of these nonnatural enzyme-catalyzed reactions are assumed to proceed through a catalytic iron porphyrin carbene (IPC) intermediate, although this intermediate has never been observed in a protein. Using crystallographic, spectroscopic,...