PNAS/Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid {alpha}-synuclein fibrils [Biochemistry]

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#16091 [ Francesco Simone Ruggeri, Fabr ] hit: 0(#ffffff)


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  DOI: 10.1073/pnas.1721220115
, The formation and spreading of amyloid aggregates from the presynaptic protein α-synuclein in the brain play central roles in the pathogenesis of Parkinson’s disease. Here, we use high-resolution atomic force microscopy to investigate the early oligomerization events of α-synuclein with single monomer angstrom resolution. We identify, visualize, and characterize directly...