PNAS/Cryo-EM structure of human mitochondrial trifunctional protein [Biochemistry]

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#16088 [ Kai Liang, Ningning Li, Xiao W ] hit: 1(#fefffe)

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a href="http://www.pnas.org/content/115/27/7039.short?rss=1"
  DOI: 10.1073/pnas.1801252115
, The mitochondrial trifunctional protein (TFP) catalyzes three reactions in the fatty acid β-oxidation process. Mutations in the two TFP subunits cause mitochondrial trifunctional protein deficiency and acute fatty liver of pregnancy that can lead to death. Here we report a 4.2-Å cryo-electron microscopy α2β2 tetrameric structure of the human TFP....

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