PNAS/Conformational control and DNA-binding mechanism of the metazoan origin recognition complex [Biochemistry]

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#16079 [ Franziska Bleichert, Alexander ] hit: 0(#ffffff)


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  DOI: 10.1073/pnas.1806315115
, In eukaryotes, the heterohexameric origin recognition complex (ORC) coordinates replication onset by facilitating the recruitment and loading of the minichromosome maintenance 2–7 (Mcm2–7) replicative helicase onto DNA to license origins. Drosophila ORC can adopt an autoinhibited configuration that is predicted to prevent Mcm2–7 loading; how the complex is activated and...