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Total posts:16,194, Original posts:16,194, Reply posts:0

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Total posts: 16,194

16104 Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes [Bioc...

DOI: 10.1073/pnas.1805862115, The lack of attachment of lipoic acid to its cognate enzyme proteins results in devastating human metabolic disorders. These mitochondrial disorders are evident soon after birth and generally result in early death. The mutations causing specific defects in lipoyl assemb... 2018-07-24 10:56:26 [Xinyun Cao, Lei Zhu, Xuejiao S]
16103 Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation [Biochemistry]

DOI: 10.1073/pnas.1803909115, Lens epithelium-derived growth factor/p75 (LEDGF/p75, or PSIP1) is a transcriptional coactivator that tethers other proteins to gene bodies. The chromatin tethering function of LEDGF/p75 is hijacked by HIV integrase to ensure viral integration at sites of active transcr... 2018-07-24 10:56:26 [Subhalakshmi Sharma, Kate]
16102 Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation [Biochemistry]

DOI: 10.1073/pnas.1803130115, Protein abnormalities in cells are the cause of major pathologies, and a number of adaptive responses have evolved to relieve the toxicity of misfolded polypeptides. To trigger these responses, cells must detect the buildup of aberrant proteins which often associate wit... 2018-07-24 10:56:26 [Anatoli B. Meriin, Arȷu]
16101 Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases [Biochemistry]

DOI: 10.1073/pnas.1806721115, Phospholipid scramblases externalize phosphatidylserine to facilitate numerous physiological processes. Several members of the structurally unrelated TMEM16 and G protein-coupled receptor (GPCR) protein families mediate phospholipid scrambling. The structure of a TMEM16... 2018-07-24 10:56:26 [Mattia Malvezzi, Kiran K. Andr]
16100 Template and primer requirements for DNA Pol {theta}-mediated end ȷoining [Biochemistry]

DOI: 10.1073/pnas.1807329115, DNA Pol θ-mediated end joining (TMEJ) is a microhomology-based pathway for repairing double-strand breaks in eukaryotes. TMEJ is also a pathway for nonspecific integration of foreign DNAs into host genomes. DNA Pol θ shares structural homology with the high-fidelity ... 2018-07-24 10:56:25 [Peng He, Wei Yang]
16099 Lipids surf the groove in scramblases [Biochemistry]

DOI: 10.1073/pnas.1809472115, Lipid membranes have many fundamental roles in biology because they establish amphipathic and highly dynamic boundaries around cellular compartments. The plasma membrane and intracellular membranes are primarily composed of phospholipids that have a hydrophilic headgrou... 2018-07-24 10:56:25 [Angela Ballesteros, Kenton J.]
16098 Inner Workings: Unlocking the molecular mechanisms behind our sense of touch [Biochemistry]

DOI: 10.1073/pnas.1808559115, Molecular biologists don’t typically conduct their research knee deep in muck, checking underground traps for an elusive mole. But Diana Bautista needed those moles to help her understand the mysterious underpinnings of humans’ sense of touch. “The mechanisms that... 2018-07-24 10:56:25 [Leah Shaffer]
16097 Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition [Biochemistry]

DOI: 10.1073/pnas.1805131115, Each of the 30 human amyloid diseases is associated with the aggregation of a particular precursor protein into amyloid fibrils. In transthyretin amyloidosis (ATTR), mutant or wild-type forms of the serum carrier protein transthyretin (TTR), synthesized and secreted by ... 2018-07-17 09:06:11 [Lorena Saelices, Kevin Chung,]
16096 Decoding on the ribosome depends on the structure of the mRNA phosphodiester backbone [Biochemistry]

DOI: 10.1073/pnas.1721431115, During translation, the ribosome plays an active role in ensuring that mRNA is decoded accurately and rapidly. Recently, biochemical studies have also implicated certain accessory factors in maintaining decoding accuracy. However, it is currently unclear whether the mRN... 2018-07-17 09:06:11 [Hannah E. Keedy, Erica N. Thom]
16095 Distinct ways of G:U recognition by conserved tRNA binding motifs [Biochemistry]

DOI: 10.1073/pnas.1807109115, Throughout three domains of life, alanyl-tRNA synthetases (AlaRSs) recognize a G3:U70 base pair in the acceptor stem of tRNAAla as the major identity determinant of tRNAAla. The crystal structure of the archaeon Archaeoglobus fulgidus AlaRS in complex with tRNAAla provi... 2018-07-17 09:06:10 [Yeeting E. Chong, Min Guo, Xia]
16094 Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid dise...

DOI: 10.1073/pnas.1802977115, Transthyretin (TTR) is a globular tetrameric transport protein in plasma. Nearly 140 single amino acid substitutions in TTR cause life-threatening amyloid disease. We report a one-of-a-kind pathological variant featuring a Glu51, Ser52 duplication mutation (Glu51_Ser52d... 2018-07-10 09:36:02 [Elena S. Klimtchuk, Tatiana Pr]
16093 Capsid protein structure, self-assembly, and processing reveal morphogenesis of the marine virophage mavirus [Biochemist...

DOI: 10.1073/pnas.1805376115, Virophages have the unique property of parasitizing giant viruses within unicellular hosts. Little is understood about how they form infectious virions in this tripartite interplay. We provide mechanistic insights into assembly and maturation of mavirus, a marine viroph... 2018-07-10 09:36:01 [Diana Born, Lukas Reuter, Ulri]
16092 Ionophoric effects of the antitubercular drug bedaquiline [Biochemistry]

DOI: 10.1073/pnas.1803723115, Bedaquiline (BDQ), an inhibitor of the mycobacterial F1Fo-ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent new target space. Several studies have recently suggested that BDQ ultimately causes mycobacter... 2018-07-10 09:36:01 [Kiel Hards, Duncan G. G. McMil]
16091 Structure of the Lassa virus glycan shield provides a model for immunological resistance [Biochemistry]

DOI: 10.1073/pnas.1803990115, Lassa virus is an Old World arenavirus endemic to West Africa that causes severe hemorrhagic fever. Vaccine development has focused on the envelope glycoprotein complex (GPC) that extends from the virion envelope. The often inadequate antibody immune response elicited b... 2018-07-10 09:36:01 [Yasunori Watanabe, Jayna Raghw]
16090 The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutL{alpha} endonuclease [Biochemi...

DOI: 10.1073/pnas.1807319115, MutLα (MLH1-PMS2 heterodimer), which acts as a strand-directed endonuclease during the initiation of eukaryotic mismatch repair, has been postulated to function as a zinc-dependent enzyme [Kosinski J, Plotz G, Guarné A, Bujnicki JM, Friedhoff P (2008) J Mol Biol 382:... 2018-07-10 09:36:01 [Shanen M. Sherrer, Elisabeth P]
16089 Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase [Biochemistry]

DOI: 10.1073/pnas.1807027115, Recently, heme proteins have been discovered and engineered by directed evolution to catalyze chemical transformations that are biochemically unprecedented. Many of these nonnatural enzyme-catalyzed reactions are assumed to proceed through a catalytic iron porphyrin car... 2018-07-10 09:36:01 [Russell D. Lewis, Marc Garcia&]
16088 O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2 [Chemistry]

DOI: 10.1073/pnas.1801850115, Protein O-glycosylation by attachment of β-N-acetylglucosamine (GlcNAc) to the Ser or Thr residue is a major posttranslational glycosylation event and is often associated with protein folding, stability, and activity. The methylation of histone H3 at Lys-27 catalyzed... 2018-07-10 09:36:01 [Pei-Wen Lo, Jiun-Jie Shie, Che]
16087 Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid {alpha}-sy...

DOI: 10.1073/pnas.1721220115, The formation and spreading of amyloid aggregates from the presynaptic protein α-synuclein in the brain play central roles in the pathogenesis of Parkinson’s disease. Here, we use high-resolution atomic force microscopy to investigate the early oligomerization even... 2018-07-10 09:36:01 [Francesco Simone Ruggeri, Fabr]
16086 Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell d...

DOI: 10.1073/pnas.1801909115, Bivalent chromatin domains containing repressive H3K27me3 and active H3K4me3 modifications are barriers for the expression of lineage-specific genes in ES cells and must be resolved for the transcription induction of these genes during differentiation, a process that re... 2018-07-03 13:26:04 [Yuan Gao, Haiyun Gan, Zhenkun]
16085 Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis [Bioc...

DOI: 10.1073/pnas.1804869115, Tobacco smoke (TS) contains numerous cancer-causing agents, with polycyclic aromatic hydrocarbons (PAHs) and nitrosamines being most frequently cited as the major TS human cancer agents. Many lines of evidence seriously question this conclusion. To resolve this issue, w... 2018-07-03 13:26:04 [Mao-wen Weng, Hyun-Wook Lee, S]
16084 Reply to Agarwal: Activity against nuclear substrates is not necessarily mediated by nuclear Akt [Biological Sciences]

DOI: 10.1073/pnas.1808882115, The phosphorylation of Akt substrates in subcellular compartments other than the plasma membrane has previously been proposed to be mediated by the diffusion of activated Akt (1, 2). While this neatly accounts for the observation that Akt is activated by growth factors ... 2018-07-03 13:26:04 [Thomas A. Leonard]
16083 How to explain the AKT phosphorylation of downstream targets in the wake of recent findings [Biological Sciences]

DOI: 10.1073/pnas.1808461115, AKT (v-Akt oncogene), a Ser/Thr protein kinase, was also identified as protein kinase B (PKB) (reviewed in ref. 1). There are three known isoforms of AKT1-3. All these AKT isoforms are highly conserved and are recruited to the plasma membrane where they bind to PIP3,4,5... 2018-07-03 13:26:04 [Anil K. Agarwal]
16082 Crystal structures of a [NiFe] hydrogenase large subunit HyhL in an immature state in complex with a Ni chaperone HypA [...

DOI: 10.1073/pnas.1801955115, Ni-Fe clusters are inserted into the large subunit of [NiFe] hydrogenases by maturation proteins such as the Ni chaperone HypA via an unknown mechanism. We determined crystal structures of an immature large subunit HyhL complexed with HypA from Thermococcus kodakarensis... 2018-07-03 13:26:03 [Sunghark Kwon, Satoshi Watanab]
16081 Cryo-EM structure of human mitochondrial trifunctional protein [Biochemistry]

DOI: 10.1073/pnas.1801252115, The mitochondrial trifunctional protein (TFP) catalyzes three reactions in the fatty acid β-oxidation process. Mutations in the two TFP subunits cause mitochondrial trifunctional protein deficiency and acute fatty liver of pregnancy that can lead to death. Here we re... 2018-07-03 13:26:03 [Kai Liang, Ningning Li, Xiao W]
16080 Mechanistic insights into GLUT1 activation and clustering revealed by super-resolution imaging [Biochemistry]

DOI: 10.1073/pnas.1803859115, The glucose transporter GLUT1, a plasma membrane protein that mediates glucose homeostasis in mammalian cells, is responsible for constitutive uptake of glucose into many tissues and organs. Many studies have focused on its vital physiological functions and close relati... 2018-07-03 13:26:03 [Qiuyan Yan, Yanting Lu, Lulu Z]
16079 Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer [Biochemis...

DOI: 10.1073/pnas.1805855115, Cellular membranes are maintained as closed compartments, broken up only transiently during membrane reorganization or lipid transportation. However, open-ended membranes, likely derived from scissions of the endoplasmic reticulum, persist in vaccinia virus-infected cel... 2018-07-03 13:26:03 [Prabhat Kumar Pathak, Shuxia P]
16078 An archaeal primase functions as a nanoscale caliper to define primer length [Biochemistry]

DOI: 10.1073/pnas.1806351115, The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3′ OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by DNA primase. The primase of archaea and eukaryotes, despite having var... 2018-06-26 09:16:59 [Jiangyu Yan, Sandro Holzer, Lu]
16077 Lipid binding attenuates channel closure of the outer membrane protein OmpF [Biochemistry]

DOI: 10.1073/pnas.1721152115, Strong interactions between lipids and proteins occur primarily through association of charged headgroups and amino acid side chains, rendering the protonation status of both partners important. Here we use native mass spectrometry to explore lipid binding as a function... 2018-06-26 09:16:59 [Idlir Liko, Matteo T. Degiacom]
16076 Conformational control and DNA-binding mechanism of the metazoan origin recognition complex [Biochemistry]

DOI: 10.1073/pnas.1806315115, In eukaryotes, the heterohexameric origin recognition complex (ORC) coordinates replication onset by facilitating the recruitment and loading of the minichromosome maintenance 2–7 (Mcm2–7) replicative helicase onto DNA to license origins. Drosophila ORC can adopt an... 2018-06-26 09:16:59 [Franziska Bleichert, Alexander]
16075 Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis [Bioche...

DOI: 10.1073/pnas.1801745115, Obesity and related metabolic diseases are becoming worldwide epidemics that lead to increased death rates and heavy health care costs. Effective treatment options have not been found yet. Here, based on the observation that baicalin, a flavonoid from the herbal medicin... 2018-06-26 09:16:59 [Jianye Dai, Kai Liang, Shan Zh]

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