PNAS

You need to login to add new posts.

You need to login to add reply.

You can view the posts.

Total posts:16,194, Original posts:16,194, Reply posts:0

1
2
3

Total posts: 16,194

16194 SIR proteins create compact heterochromatin fibers [Biochemistry]

DOI: 10.1073/pnas.1810647115, Heterochromatin is a silenced chromatin region essential for maintaining genomic stability and driving developmental processes. The complicated structure and dynamics of heterochromatin have rendered it difficult to characterize. In budding yeast, heterochromatin assemb... 2018-12-04 09:11:23 [Sarah G. Swygert, Subhadip Sen]
16193 Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins [Bio...

DOI: 10.1073/pnas.1816614115, A-kinase anchoring proteins (AKAPs) shape second-messenger signaling responses by constraining protein kinase A (PKA) at precise intracellular locations. A defining feature of AKAPs is a helical region that binds to regulatory subunits (RII) of PKA. Mining patient-deriv... 2018-12-04 09:11:23 [F. Donelson Smith, Mitchell H.]
16192 Design and in vitro realization of carbon-conserving photorespiration [Biochemistry]

DOI: 10.1073/pnas.1812605115, Photorespiration recycles ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) oxygenation product, 2-phosphoglycolate, back into the Calvin Cycle. Natural photorespiration, however, limits agricultural productivity by dissipating energy and releasing CO2. Several ... 2018-12-04 09:11:23 [Devin L. Trudeau, Christian Ed]
16191 Metabolic programming a lean phenotype by deregulation of RNA polymerase III [Biochemistry]

DOI: 10.1073/pnas.1815590115, As a master negative regulator of RNA polymerase (Pol) III, Maf1 modulates transcription in response to nutrients and stress to balance the production of highly abundant tRNAs, 5S rRNA, and other small noncoding RNAs with cell growth and maintenance. This regulation of ... 2018-11-27 10:26:27 [Ian M. Willis, Robyn D. Moir,]
16190 Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment...

DOI: 10.1073/pnas.1803446115, Class IA PI3Ks have many roles in health and disease. The rules that govern intersubunit and receptor associations, however, remain unclear. We engineered mouse lines in which individual endogenous class IA PI3K subunits were C-terminally tagged with 17aa that could be ... 2018-11-27 10:26:27 [N. Tsolakos, T. N. Durrant, T.]
16189 Genome-wide RNA structurome reprogramming by acute heat shock globally regulates mRNA abundance [Biochemistry]

DOI: 10.1073/pnas.1807988115, The heat shock response is crucial for organism survival in natural environments. RNA structure is known to influence numerous processes related to gene expression, but there have been few studies on the global RNA structurome as it prevails in vivo. Moreover, how heat ... 2018-11-27 10:26:27 [Zhao Su, Yin Tang, Laura E. Ri]
16188 Multiple prebiotic metals mediate translation [Earth, Atmospheric, and Planetary Sciences]

DOI: 10.1073/pnas.1803636115, Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life’s oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a functional anc... 2018-11-27 10:26:27 [Marcus S. Bray, Timothy K. Len]
16187 Histone H3 lysine 4 methylation signature associated with human undernutrition [Biochemistry]

DOI: 10.1073/pnas.1722125115, Chronically undernourished children become stunted during their first 2 years and thereafter bear burdens of ill health for the rest of their lives. Contributors to stunting include poor nutrition and exposure to pathogens, and parental history may also play a role. How... 2018-11-27 10:26:27 [Robin Uchiyama, Kristyna Kupko]
16186 Histone tails decrease N7-methyl-2'-deoxyguanosine depurination and yield DNA-protein cross-links in nucleosome core...

DOI: 10.1073/pnas.1813338115, Monofunctional alkylating agents preferentially react at the N7 position of 2′-deoxyguanosine in duplex DNA. Methylated DNA, such as that produced by methyl methanesulfonate (MMS) and temozolomide, exists for days in organisms. The predominant consequence of N7-methyl... 2018-11-27 10:26:27 [Kun Yang, Daeyoon Park, Natali]
16185 Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes [Biochemistry]

DOI: 10.1073/pnas.1808576115, Biotransformation enzymes ensure a viable homeostasis by regulating reversible cycles of oxidative and reductive reactions. The metabolism of nitrogen-containing compounds is of high pharmaceutical and toxicological relevance because N-oxygenated metabolites derived fro... 2018-11-20 09:01:25 [Christian Kubitza, Florian Bit]
16184 Crystal structure of heme A synthase from Bacillus subtilis [Biochemistry]

DOI: 10.1073/pnas.1813346115, Heme A is an essential cofactor for respiratory terminal oxidases and vital for respiration in aerobic organisms. The final step of heme A biosynthesis is formylation of the C-8 methyl group of heme molecule by heme A synthase (HAS). HAS is a heme-containing integral me... 2018-11-20 09:01:25 [Satomi Niwa, Kazuki Takeda, Ma]
16183 Optimal molecular crowding accelerates group II intron folding and maximizes catalysis [Biochemistry]

DOI: 10.1073/pnas.1806685115, Unlike in vivo conditions, group II intron ribozymes are known to require high magnesium(II) concentrations ([Mg2+]) and high temperatures (42 °C) for folding and catalysis in vitro. A possible explanation for this difference is the highly crowded cellular environmen... 2018-11-20 09:01:25 [Bishnu P. Paudel, Erica Fiorin]
16182 Deciphering the structure of the condensin protein complex [Biochemistry]

DOI: 10.1073/pnas.1812770115, Protein assemblies consisting of structural maintenance of chromosomes (SMC) and kleisin subunits are essential for the process of chromosome segregation across all domains of life. Prokaryotic condensin belonging to this class of protein complexes is composed of a homo... 2018-11-20 09:01:25 [Dana Krepel, Ryan R. Cheng, Mi]
16181 Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERB{alpha} c...

DOI: 10.1073/pnas.1805397115, The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as a REV-ERBα−interacting... 2018-11-20 09:01:25 [Alexandre Berthier, Manȷ]
16180 News Feature: Exposing the exposome to elucidate disease [Chemistry]

DOI: 10.1073/pnas.1817771115, Environmental factors, not genes constitute most disease risk. Myriad approaches are attempting to use the latest science and technology to more clearly reveal the complex mix of pollutants that contribute. Google Street View cars traversing the roads of Oakland, CA, on... 2018-11-20 09:01:24 [Carolyn Beans]
16179 KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway [Biochemistry]

DOI: 10.1073/pnas.1805662115, Janus tyrosine kinase 2 (JAK2)−signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2−STAT3 signaling pathway is frequently associat... 2018-11-13 12:16:16 [Hyunkyung Kim, Dongha Kim, Seo]
16178 SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis [Biochemistry]

DOI: 10.1073/pnas.1720352115, Dephosphorylation of the inhibitory “S259” site on RAF kinases (S259 on CRAF, S365 on BRAF) plays a key role in RAF activation. The MRAS GTPase, a close relative of RAS oncoproteins, interacts with SHOC2 and protein phosphatase 1 (PP1) to form a heterotrimeric holoe... 2018-11-06 10:41:44 [Lucy C. Young, Nicole Hartig,]
16177 Small-molecule CaV{alpha}1⋅CaV{beta} antagonist suppresses neuronal voltage-gated calcium-channel trafficking [Biochem...

DOI: 10.1073/pnas.1813157115, Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the postsynaptic centra... 2018-11-06 10:41:44 [Xingjuan Chen, Degang Liu, Don]
16176 Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated ...

DOI: 10.1073/pnas.1808733115, Calmodulin (CaM) represents one of the most conserved proteins among eukaryotes and is known to bind and modulate more than a 100 targets. Recently, several disease-associated mutations have been identified in the CALM genes that are causative of severe cardiac arrhythm... 2018-11-06 10:41:44 [Kaiqian Wang, Christian Holt,]
16175 Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii...

DOI: 10.1073/pnas.1811167115, Parasites of the phylum Apicomplexa are responsible for significant morbidity and mortality on a global scale. Central to the virulence of these pathogens are the phylum-specific, unconventional class XIV myosins that power the essential processes of parasite motility a... 2018-11-06 10:41:44 [Cameron J. Powell, Raghavendra]
16174 Pervasive tertiary structure in the dengue virus RNA genome [Biochemistry]

DOI: 10.1073/pnas.1716689115, RNA virus genomes are efficient and compact carriers of biological information, encoding information required for replication both in their primary sequences and in higher-order RNA structures. However, the ubiquity of RNA elements with higher-order folds—in which hel... 2018-11-06 10:41:43 [Elizabeth A. Dethoff, Mark A.]
16173 Hierarchical spidroin micellar nanoparticles as the fundamental precursors of spider silks [Chemistry]

DOI: 10.1073/pnas.1810203115, Many natural silks produced by spiders and insects are unique materials in their exceptional toughness and tensile strength, while being lightweight and biodegradable–properties that are currently unparalleled in synthetic materials. Myriad approaches have been attemp... 2018-11-06 10:41:43 [Lucas R. Parent, David Onofrei]
16172 Transcription initiation defines kinetoplast RNA boundaries [Biochemistry]

DOI: 10.1073/pnas.1808981115, Mitochondrial genomes are often transcribed into polycistronic RNAs punctuated by tRNAs whose excision defines mature RNA boundaries. Although kinetoplast DNA lacks tRNA genes, it is commonly held that in Trypanosoma brucei the monophosphorylated 5′ ends of functional... 2018-10-30 09:46:29 [Francois M. Sement, Takuma Sue]
16171 Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomyc...

DOI: 10.1073/pnas.1800502115, Understanding how antibiotic-producing bacteria deal with highly reactive chemicals will ultimately guide therapeutic strategies to combat the increasing clinical resistance crisis. Here, we uncovered a distinctive self-defense strategy featured by a secreted oxidoreduc... 2018-10-30 09:46:28 [Yue Zhang, Wan-Hong Wen, Jin-Y]
16170 Mechanism of tRNA-mediated +1 ribosomal frameshifting [Biochemistry]

DOI: 10.1073/pnas.1809319115, Accurate translation of the genetic code is critical to ensure expression of proteins with correct amino acid sequences. Certain tRNAs can cause a shift out of frame (i.e., frameshifting) due to imbalances in tRNA concentrations, lack of tRNA modifications or insertions... 2018-10-30 09:46:28 [Samuel Hong, S. Sunita, Tatsuy]
16169 Culmination of a half-century quest reveals insight into mutant tRNA-mediated frameshifting after tRNA departure from th...

DOI: 10.1073/pnas.1815837115, The pairing of the three anticodon bases of a cognate acylated tRNA to a ribosomal aminoacyl (A)-site three-base codon and the concerted movement of this bound complex into the ribosomal peptidyl (P) site are central to standard nonoverlapping triplet decoding. Subseque... 2018-10-30 09:46:28 [John F. Atkins]
16168 Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase [Biochemistry]

DOI: 10.1073/pnas.1810457115, Cross-over recombination products are a hallmark of meiosis because they are necessary for accurate chromosome segregation and they also allow for increased genetic diversity during sexual reproduction. However, cross-overs can also cause gross chromosomal rearrangement... 2018-10-23 11:16:58 [J. Brooks Crickard, Kyle Kanie]
16167 Molecular mechanism of activation of the immunoregulatory amidase NAAA [Biochemistry]

DOI: 10.1073/pnas.1811759115, Palmitoylethanolamide is a bioactive lipid that strongly alleviates pain and inflammation in animal models and in humans. Its signaling activity is terminated through degradation by N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase expressed at high levels in... 2018-10-23 11:16:58 [Alexei Gorelik, Ahmad Gebai, K]
16166 The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 [Biochemistry]

DOI: 10.1073/pnas.1805593115, SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that depletes cellular dNTPs in noncycling cells to promote genome stability and to inhibit retroviral and herpes viral replication. In addition to being substrates, cellular nucleotides also alloste... 2018-10-23 11:16:58 [Kirsten M. Knecht, Olga Buzove]
16165 Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 ...

DOI: 10.1073/pnas.1810524115, Canonical inflammasomes are cytosolic supramolecular complexes that activate caspase-1 upon sensing extrinsic microbial invasions and intrinsic sterile stress signals. During inflammasome assembly, adaptor proteins ASC and NLRC4 recruit caspase-1 through homotypic caspa... 2018-10-23 11:16:57 [Yang Li, Tian-Min Fu, Alvin Lu]

1
2
3

PNAS

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Tools