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Total posts: 1,287

1287 Helicobacter pylori helicase loader protein Hp0897 shows unique functions of N- and C-terminal regions

DOI: 10.1042/BCJ20190430, Helicase loaders are required for the loading of helicases at the vicinity of replication origins. In Helicobacter pylori , Hp0897 has been shown to be a potential helicase loader for replicative helicase (HpDnaB) although it does not show any sequence homology with convent... 2019-09-23 03:32:21 [Kumar, A., Saha, A., Verma, V.]
1286 Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2

DOI: 10.1042/BCJ20190569, HAX-1, a multifunctional protein involved in cell proliferation, calcium homeostasis, and regulation of apoptosis, is a promising therapeutic target. It regulates apoptosis through multiple pathways, understanding of which is limited by obscurity of its structural details a... 2019-09-23 03:32:21 [Chaganti, L. K., Dutta, S., Ku]
1285 Biochemical characterization of phosphoenolpyruvate carboxykinases from Arabidopsis thaliana

DOI: 10.1042/BCJ20190523, ATP-dependent phospho enol pyruvate carboxykinases (PEPCKs, EC 4.1.1.49) from C4 and CAM plants have been widely studied due to their crucial role in photosynthetic CO2 fixation. However, our knowledge on the structural, kinetic and regulatory properties of the enzymes from... 2019-09-23 03:32:21 [Rojas, B. E., Hartman, M. D.,]
1284 Insulin and {beta}-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 di...

DOI: 10.1042/BCJ20190594, Control of fatty acid storage and release in adipose tissue is fundamental in energy homeostasis and the development of obesity and type 2 diabetes. We here take the whole signalling network into account to identify how insulin and β-adrenergic stimulation in concert con... 2019-09-20 08:29:39 [Jonsson, C., Castor Batista, A]
1283 A Candidate Activation Pathway for Coagulation Factor VII

DOI: 10.1042/BCJ20190595, The mechanism of generation of factor VIIa, considered the initiating protease in the tissue factor-initiated extrinsic limb of blood coagulation, is obscure. Decreased levels of plasma VIIa in individuals with congenital factor IX deficiency suggest that generation of VIIa... 2019-09-19 03:42:20 [Misenheimer, T. M., Kumfer, K.]
1282 Folate deficiency promotes differentiation of vascular smooth muscle cells without affecting the methylation status of r...

DOI: 10.1042/BCJ20190275, Elevated serum homocysteine, an intermediate of cellular one-carbon metabolism, is an independent risk factor for cardiovascular disease (CVD). Folate deficiency increases serum homocysteine and may contribute to CVD progression. Vascular smooth muscle cells regulate vascul... 2019-09-17 03:41:07 [Kolb, A. F., Petrie, L., Mayer]
1281 {-}{-}{-}{-}Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway ...

DOI: 10.1042/BCJ20190410, Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that regulates activation of the c-Jun N-terminal kinase (JNK)- and p38-stress response pathways leading to apoptosis in nucleated cells. We have previously shown that A... 2019-09-17 03:41:07 [Patel, P., Naik, M. U., Golla,]
1280 Selective degradation of plasmid-derived mRNAs by MCPIP1 RNase

DOI: 10.1042/BCJ20190646, Detection and degradation of foreign nucleic acids is an ancient form of host defense. However, the underlying mechanisms are not completely clear. MCPIP1 is an endoribonuclease and an important regulator in both innate and adaptive immunity by targeting inflammatory mRNA d... 2019-09-17 03:41:07 [Qian, Y., Li, X., Miao, R., Li]
1279 Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease pati...

DOI: 10.1042/BCJ20190315, Leucine-rich repeat kinase 2 is a promising therapeutic target for the treatment of Parkinson's disease, and orally bioavailable, brain penetrant and highly potent LRRK2 kinase inhibitors are in early stages of clinical testing. Detection of LRRK2 phosphorylation, as we... 2019-09-16 06:06:51 [Fernandez, B., Lara Ordonez, A]
1278 Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transpor...

DOI: 10.1042/BCJ20190504, Coxiella burnetii is a Gram-negative bacterium which causes Q fever, a complex and life-threatening infection with both acute and chronic presentations. C. burnetii invades a variety of host cell types and replicates within a unique vacuole derived from the host cell lysoso... 2019-09-16 06:06:51 [Kuba, M., Neha, N., De Souza,]
1277 Insulin and {beta}-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 di...

DOI: 10.1042/BCJ20190594, Control of fatty acid storage and release in adipose tissue is fundamental in energy homeostasis and the development of obesity and type 2 diabetes. We here take the whole signalling network into account to identify how insulin and β-adrenergic stimulation in concert con... 2019-09-13 03:38:52 [Stralfors, P., Jonsson, C., Ca]
1276 Crystal structure of human zinc-{alpha}2- glycoprotein in complex with fatty acid reveals multiple different modes of li...

DOI: 10.1042/BCJ20190354, Human zinc-α2-glycoprotein (ZAG) is a 42 kDa adipokine which regulates body fat mass and is associated with cachexia and obesity. ZAG belongs to the major histocompatibility complex class I protein family and binds long chain polyunsaturated fatty acids in its groove for... 2019-09-10 03:44:40 [Lau, A. M., Zahid, H., Gor, J.]
1275 Comparison of type 5d autotransporter phospholipases demonstrates a correlation between high activity and intracellular ...

DOI: 10.1042/BCJ20190136, Autotransporters, or type 5 secretion systems, are widespread surface proteins of Gram-negative bacteria often associated with virulence functions. Autotransporters consist of an outer membrane β-barrel domain and an exported passenger. In the poorly studied type 5d subc... 2019-09-06 04:15:30 [Trunk, T., Casasanta, M. A., Y]
1274 Molecular, Chemical, and Structural Characterization of Prostaglandin A2 as a Novel Agonist for Nur77

DOI: 10.1042/BCJ20190253, Nur77 is a transcription factor belonging to the NR4A subfamily of nuclear hormone receptors. Upon induction, Nur77 modulates expression of its target genes and controls a variety of biological and pathophysiological processes. Prior research that revealed a structurally at... 2019-09-06 04:15:30 [Lakshmi, S. P., Reddy, A. T.,]
1273 Structural Insights into Escherichia coli Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometr...

DOI: 10.1042/BCJ20190318, CoaBC, part of the vital coenzyme A biosynthetic pathway in bacteria, has recently been validated as a promising antimicrobial target. In this work, we employed native ion mobility-mass spectrometry to gain structural insights into the phosphopantothenoylcysteine synthetase... 2019-09-05 03:27:25 [Chan, D. S.-H., Hess, J., Shaw]
1272 Membrane-Associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha c...

DOI: 10.1042/BCJ20190577, Interleukin 6 (IL6) is a cytokine that regulates a number of important immune and inflammatory pathways. We used the ability of IL6 to inhibit the clonal proliferation of the mouse M1 myeloid leukemia cell line in agar to positively screen a cDNA expression library for prot... 2019-09-05 03:27:25 [Babon, J. J., Stockwell, D., D]
1271 Conserved bases for the initial cyclase in gibberellin biosynthesis: from bacteria to plants

DOI: 10.1042/BCJ20190479, All land plants contain at least one class II diterpene cyclase (DTC), which utilize an acid-base catalytic mechanism, for the requisite production of ent -copalyl diphosphate ( ent -CPP) in gibberellin A (GA) phytohormone biosynthesis. These ent -CPP synthases (CPSs) are h... 2019-09-04 03:39:08 [Lemke, C., Potter, K. C., Schu]
1270 Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the i...

DOI: 10.1042/BCJ20190254, Misfolded proteins in the endoplasmic reticulum (ER) are removed through multistep processes termed ER-associated degradation (ERAD). Valosin-containing protein (VCP) plays a crucial role in ERAD as the interaction of ubiquitin fusion degradation protein 1 (Ufd1) with VCP v... 2019-09-02 04:02:37 [Nguyen, Q.-A. T., Choi, J., Ya]
1269 Rubisco activation by wheat Rubisco activase isoform 2{beta} is insensitive to inhibition by ADP

DOI: 10.1042/BCJ20190110, Rubisco activase (Rca) is a catalytic chaperone that remodels the active site, promotes the release of inhibitors and restores catalytic competence to Rubisco. Rca activity and its consequent effect on Rubisco activation and photosynthesis are modulated by changes to the ch... 2019-08-30 06:19:44 [Perdomo, J. A., Degen, G. E.,]
1268 Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron

DOI: 10.1042/BCJ20190418, Squalene monooxygenase (SM) is an essential rate-limiting enzyme in cholesterol synthesis. SM degradation is accelerated by excess cholesterol, and this requires the first 100 amino acids of SM (SM N100). This process is part of a protein quality control pathway called endo... 2019-08-30 06:19:44 [Chua, N. K., Scott, N. A., Bro]
1267 A polyamine-independent role for S-adenosylmethionine decarboxylase

DOI: 10.1042/BCJ20190561, The only known function of S -adenosylmethionine decarboxylase (AdoMetDC) is to supply, with its partner aminopropyltransferase enzymes such as spermidine synthase (SpdSyn), the aminopropyl donor for polyamine biosynthesis. Polyamine spermidine is probably essential for gro... 2019-08-29 03:39:28 [Li, B., Kurihara, S., Kim, S.]
1266 Crystal structures of Magnaporthe oryzae trehalose-6-phosphate synthase (MoTps1) suggest a model for catalytic process o...

DOI: 10.1042/BCJ20190289, Trehalose-6-phosphate (T6P) synthase (Tps1) catalyses the formation of T6P from UDP-glucose (UDPG) (or GDPG, etc.) and glucose-6-phosphate (G6P), and structural basis of this process has not been well studied. MoTps1 ( Magnaporthe oryzae Tps1) plays critical role in carbon ... 2019-08-27 03:35:24 [Wang, S., Zhao, Y., Yi, L., Sh]
1265 RhoBTB1 interacts with ROCKs and inhibits invasion

DOI: 10.1042/BCJ20190203, RhoBTB1 is an atypical Rho GTPase with two BTB domains in addition to its Rho domain. Although most Rho GTPases regulate actin cytoskeletal dynamics, RhoBTB1 is not known to affect cell shape or motility. We report that RhoBTB1 depletion increases prostate cancer cell invas... 2019-08-20 04:37:23 [Haga, R. B., Garg, R., Collu,]
1264 Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senes...

DOI: 10.1042/BCJ20190405, Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and a... 2019-08-20 03:43:07 [Martinez, J., Tarallo, D., Mar]
1263 Interactions between motor domains in kinesin-14 Ncd - a molecular dynamics study

DOI: 10.1042/BCJ20190484, Minus-end directed, non-processive kinesin-14 Ncd is a dimeric protein with C-terminally located motor domains (heads). Generation of the power-stroke by Ncd consists in a lever-like rotation of a long superhelical 'stalk' segment while one of the kinesin's head... 2019-08-15 03:44:21 [Ludwiczak, J., Szczęsna]
1262 The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methyl-malonyl-CoA

DOI: 10.1042/BCJ20190500, Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be promiscuous as it may use methylmalonyl-CoA instead of malonylCoA and thereby introduce methyl-branches. We have rec... 2019-08-15 03:44:21 [Dewulf, J. P., Gerin, I., Ride]
1261 A novel small molecule A2A receptor agonist, indirubin-3'-monoxime, alleviates lipid-induced inflammation and insuli...

DOI: 10.1042/BCJ20190251, Saturated free fatty acid induced adipocyte inflammation plays a pivotal role in implementing insulin resistance and type 2 diabetes. Recent reports suggest A2A adenosine receptor (A2AAR) could be an attractive choice to counteract adipocyte inflammation and insulin resista... 2019-08-13 06:19:42 [Choudhary, S. A., Bora, N., Ba]
1260 Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimul...

DOI: 10.1042/BCJ20190383, DHX8 is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the spliceosome. Here we report the biochemical characterization of full-length human DHX8 and the catalytically active helicase core DHX8547, alongside crystal str... 2019-08-13 06:19:42 [Felisberto-Rodrigues, C., Thom]
1259 Broken Force Dispersal Network in Tip-links by the Mutations at the Ca2+-binding Residues induces Hearing-Loss

DOI: 10.1042/BCJ20190453, Tip-link as force-sensor in hearing conveys the mechanical force originating from sound to ion-channels while maintaining the integrity of the entire sensory assembly in inner-ear. This delicate balance between structure and function of tip-links is regulated by Ca2+-ions p... 2019-08-09 08:06:19 [Hazra, J. P., Sagar, A., Arora]
1258 Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells

DOI: 10.1042/BCJ20190375, Hepsin is a transmembrane serine protease implicated in many biological processes, including hepatocyte growth, urinary protein secretion, auditory nerve development, and cancer metastasis. Zymogen activation is critical for hepsin function. To date, how hepsin is activated... 2019-08-08 03:54:44 [Wang, L., Zhang, C., Sun, S.,]

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