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Total posts: 1,239

1239 Nitration-Induced Ubiquitination and Degradation Control Quality of ERK1

DOI: 10.1042/BCJ20190240, The mitogen-activated protein kinase ERK1/2 (ERKs) play important roles in a wide spectrum of cellular processes and have been implicated in a number of disease states. The spatiotemporal regulation of ERKs activity has been extensively studied. However, scarce information ... 2019-06-13 03:29:12 [Zhang, Y., Huang, X., Wang, J.]
1238 DEK Terminates Diapause by Activation of Quiescent Cells in the Crustacean Artemia

DOI: 10.1042/BCJ20190169, To cope with harsh environments the Artemia shrimp produces gastrula embryos in diapause, a state of obligate dormancy, having cellular quiescence and suppressed metabolism. The mechanism behind these cellular events remains largely unknown. Here, we study the regulation of... 2019-06-12 07:58:10 [Jia, W.-H., Li, A.-Q., Feng, J]
1237 AMP-activated protein kinase complexes containing the {beta}2 regulatory subunit are upregulated during and contribute t...

DOI: 10.1042/BCJ20180714, AMP-activated protein kinase (AMPK) is a heterotrimer of α catalytic and β and regulatory subunits that acts to regulate cellular and whole-body nutrient metabolism. The key role of AMPK in sensing energy status has led to significant interest in AMPK as a therapeutic ta... 2019-06-12 04:36:54 [Katwan, O. J., Alghamdi, F., A]
1236 The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: Redox as an upstream...

DOI: 10.1042/BCJ20190077, Calcium signaling is essential for embryonic development but the signals upstream of calcium are only partially understood. Here we investigate the role of the intracellular glutathione redox potential in calcium signaling using the Chac1 protein of zebrafish. A member of t... 2019-06-12 04:36:53 [Yadav, S., Chawla, B., Khurshe]
1235 Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors wit...

DOI: 10.1042/BCJ20190288, Strigolactones are multifunctional plant hormones regulating essential physiological processes affecting growth and development. In vascular plants, strigolactones are recognized by α/β hydrolase fold proteins from the D14/DAD2 family in the initial step of the signallin... 2019-06-11 03:58:42 [Hamiaux, C., Larsen, L., Lee,]
1234 Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in ...

DOI: 10.1042/BCJ20190336, Thiol-based redox regulation is crucial for adjusting chloroplast functions under fluctuating light environments. We recently discovered that the thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP) redox cascade supports oxidative thiol modulation by using hydrogen peroxide... 2019-06-06 04:53:38 [Yoshida, K., Uchikoshi, E., Ha]
1233 Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase

DOI: 10.1042/BCJ20190143, In addition to nitric oxide (NO) synthases, molybdenum-dependent enzymes have been reported to reduce nitrite to produce NO. Here, we report the stoichiometric reduction of nitrite to NO by human sulfite oxidase, a mitochondrial intermembrane space enzyme primarily involved... 2019-06-05 04:59:38 [Bender, D., Kaczmarek, A. T.,]
1232 The ChlD subunit links the motor and porphyrin binding subunits of magnesium chelatase

DOI: 10.1042/BCJ20190095, Magnesium chelatase initiates chlorophyll biosynthesis, catalysing the MgATP2- dependent insertion of a Mg2+ ion into protoporphyin IX. The catalytic core of this large enzyme complex consists of three subunits: Bch/ChlI, Bch/ChlD and Bch/ChlH (in bacteriochlorophyll and ch... 2019-06-04 04:46:04 [Farmer, D. A., Brindley, A. A.]
1231 The search for candidate genes associated with natural variation of grain Zn accumulation in barley

DOI: 10.1042/BCJ20190181, Combating Hidden Hunger through molecular breeding of nutritionally enriched crops requires a better understanding of micronutrient accumulation. We studied natural variation in grain micronutrient accumulation in barley ( Hordeum vulgare L.) and searched for candidate gene... 2019-06-04 04:46:04 [Detterbeck, A., Nagel, M., Ren]
1230 The {beta}-hairpin region of cyanobacterial F1-ATPase {gamma} subunit plays a regulatory role in the enzyme activity

DOI: 10.1042/BCJ20190242, The subunit of cyanobacterial and chloroplast ATP synthase, the rotary shaft of F1-ATPase, equips a specific insertion region that is only observed in photosynthetic organisms. This region plays a physiologically pivotal role in enzyme regulation, such as in ADP inhibition ... 2019-06-04 04:46:04 [Akiyama, K., Kondo, K., Inabe,]
1229 The Histidine-rich Loop in the Extracellular Domain of ZIP4 Binds Zinc and Plays a Role in Zinc Transport

DOI: 10.1042/BCJ20190108, The Zrt-/Irt-like protein (ZIP) family mediates zinc influx from extracellular space or intracellular vesicles/organelles, playing a central role in systemic and cellular zinc homeostasis. Out of the 14 family members encoded in human genome, ZIP4 is exclusively responsible... 2019-06-04 04:46:03 [Zhang, T., Kuliyev, E., Sui, D]
1228 Histone demethylase KDM6B regulates human podocyte differentiation in vitro

DOI: 10.1042/BCJ20180968, Podocytes are terminally differentiated and highly specialized glomerular cells, which have an essential role as a filtration barrier against proteinuria. Histone methylation has been shown to influence cell development, but its role on podocyte differentiation is less unde... 2019-05-28 08:53:14 [Guo, Y., Xiong, Z., Guo, X.]
1227 Specific Keratinase Derived Designer Peptides Potently Inhibit A{beta} Aggregation Resulting in Reduced Neuronal Toxicit...

DOI: 10.1042/BCJ20190183, Compelling evidences implicate self-assembly of amyloid- β (A β 1-42) peptides into soluble oligomers and fibrils as a major underlying event in Alzheimer's disease (AD) pathogenesis. Herein, we employed amyloid-degrading keratinase (kerA) enzyme as a key A β 1-42-bi... 2019-05-28 08:53:14 [Rajput, R., G L, B., Srivastav]
1226 Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling

DOI: 10.1042/BCJ20190302, GCN5L1 regulates protein acetylation and mitochondrial energy metabolism in diverse cell types. In the heart, loss of GCN5L1 sensitizes the myocardium to injury from exposure to nutritional excess and ischemia/reperfusion injury. This phenotype is associated with the reduce... 2019-05-28 08:53:14 [Manning, J. R., Thapa, D., Zha]
1225 Binding properties of the quaternary assembly protein SPAG1

DOI: 10.1042/BCJ20190198, In cells, many constituents are able to assemble resulting in large macromolecular machineries possessing very specific biological and physiological functions, e.g., ribosome, spliceosome and proteasome. Assembly of such entities is commonly mediated by transient protein fa... 2019-05-22 07:27:54 [Chagot, M.-E., Dos Santos Mora]
1224 PP2C phosphatase Pic1 negatively regulates phosphorylation status of Pti1b kinase, a regulator of flagellin-triggered im...

DOI: 10.1042/BCJ20190299, Plant immune responses, including the production of reactive oxygen species (ROS), are triggered when pattern recognition receptors (PRR) become activated upon detection of microbe-associated molecular patterns (MAMPs). Receptor-like cytoplasmic kinases are key components o... 2019-05-16 08:00:31 [Giska, F., Martin, G. B.]
1223 Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism

DOI: 10.1042/BCJ20180939, The absorption of dietary iron is influenced by numerous dietary and physiological factors. We have previously demonstrated that zinc treatment of intestinal cells increases iron absorption via induction of the apical membrane iron transporter divalent metal iron transporte... 2019-05-15 06:42:14 [Kondaiah, P., Aslam, M. F., Ma]
1222 Tissue-Specific Characterization of Mitochondrial Branched-Chain Keto Acid Oxidation Using a Multiplexed Assay Platform

DOI: 10.1042/BCJ20190182, Alterations to branched chain-keto acid (BCKA) oxidation have been implicated in a wide variety of human diseases, ranging from diabetes to cancer. Although global shifts in BCKA metabolism-evident by gene transcription, metabolite profiling, and in vivo flux analyses have ... 2019-05-15 06:42:14 [Goldberg, E. J., Buddo, K. A.,]
1221 Plastidic glucose-6-phosphate dehydrogenase is regulated to maintain activity in the light

DOI: 10.1042/BCJ20190234, Glucose-6-phosphate dehydrogenase (G6PDH) can initiate the glucose 6-phosphate (G6P) shunt around the Calvin-Benson cycle. In order to understand the regulation of flux through this pathway, we have characterized the biochemical parameters and redox regulation of the three ... 2019-05-15 06:42:14 [Preiser, A. L., Fisher, N., Ba]
1220 Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase from Bifidobacterium kashiwanohense

DOI: 10.1042/BCJ20190206, Taurine aminotransferases catalyze the first step in taurine catabolism in many taurine-degrading bacteria, and play an important role in bacterial taurine metabolism in the mammalian gut. Here we report the biochemical and structural characterization of a new taurine:2-oxo... 2019-05-14 05:00:10 [Li, M., Wei, Y., Yin, J., Lin,]
1219 Characterization of soluble CD39 (SolCD39/NTPDase1) from Piggy-Bac nonviral system as a tool to control the nucleotides ...

DOI: 10.1042/BCJ20190040, Extracellular ATP (eATP) and its metabolites have emerged as key modulators of different diseases and comprise a complex pathway called purinergic signaling. An increased number of tools have been developed to study the role of nucleotides and nucleosides in cell proliferat... 2019-05-13 06:11:31 [Beckenkamp, L. R., Iser, I. C.]
1218 A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human bre...

DOI: 10.1042/BCJ20190177, The most aggressive and invasive tumor cells often reside in hypoxic microenvironments and rely heavily on rapid anaerobic glycolysis for energy production. This switch from oxidative phosphorylation to glycolysis, along with up-regulation of the glucose transport system, s... 2019-05-09 03:39:16 [Mboge, M. Y., Chen, Z., Khokha]
1217 Structural basis for the C-domain selective angiotensin converting enzyme inhibition by bradykinin-potentiating peptide ...

DOI: 10.1042/BCJ20190290, Angiotensin-converting enzyme (ACE) is a zinc metalloprotease best known for its role in blood pressure regulation. ACE consists of two homologous catalytic domains, the N- and C-domain, that display distinct but overlapping catalytic functions in vivo owing to subtle diffe... 2019-05-09 03:39:16 [Sturrock, E. D., Lubbe, L., Co]
1216 Screening substrate binding positions by rolling circle amplification suggesting a binding model of Nt.BstNBI

DOI: 10.1042/BCJ20190167, Nicking endonucleases (NEs) become increasingly attractive for their promising applications in isothermal amplifications. Unfortunately, in comparison with their applications, their catalytic mechanism studies have relatively lagged behind, due to a paucity of crystal struc... 2019-05-07 06:22:56 [Wei, H., Tang, S., Duan, X., G]
1215 Designing active RNF4 monomers by introducing a tryptophan: Avidity towards E2~Ub conjugates dictates the activity of ub...

DOI: 10.1042/BCJ20180883, Ubiquitin RING E3 ligases (E3s) catalyze ubiquitin (Ub) transfer to their substrates by engaging E2~Ub intermediates with the help of their RING domains. Various such E3s have been found to contain a conserved tryptophan residue in their RING that plays an essential role in... 2019-05-02 09:04:44 [Sarkar, S., Behera, A. P., Bor]
1214 Glycolic acid Attenuates UVB-induced Aquaporin-3, Matrix Metalloproteinase-9 Expression, and Collagen Degradation in Ker...

DOI: 10.1042/BCJ20180974, Ultraviolet-B exposure causes an inflammatory response, photoaged-skin, and degradation of extracellular matrix proteins including collagen and elastin. The regulation of these genes was suggested as an important mechanism to attenuate skin aging. Glycolic acid (GA) is comm... 2019-04-29 07:40:55 [Tang, S.-C., Tang, L.-C., Liu,]
1213 An acetylation mimicking mutation, K274Q, in tau imparts neurotoxicity by enhancing tau aggregation and inhibiting tubul...

DOI: 10.1042/BCJ20190042, In Alzheimer's disease, tau is predominantly acetylated at K174, K274, K280 and K281 residues. The acetylation of K274 tau is linked with memory loss and dementia. In this study, we have examined the molecular mechanism of the toxicity of acetylated K274 tau. We incorpo... 2019-04-29 07:40:55 [Rane, J. S., Kumari, A., Panda]
1212 Slc25a36 modulates pluripotency of mouse embryonic stem cells by regulating mitochondrial function and glutathione level

DOI: 10.1042/BCJ20190057, Mitochondria play a central role in the maintenance of the naïve state of embryonic stem cells. Many details of the mechanism remain to be fully elucidate. Solute carrier family 25 member 36 ( Slc25a36 ) might regulate mitochondrial function through transporting pyrimidi... 2019-04-29 07:40:55 [Xin, Y., Wang, Y., Zhong, L.,]
1211 Phosphatase of regenerating liver sensitizes MET to functional activation by hepatocyte growth factor

DOI: 10.1042/BCJ20190071, Phosphatase of regenerating liver (PRL) is overexpressed in metastatic cancers and actively drives their malignant progression. A number of studies on cultured cancer cells have implied PRL overexpression as a stimulant for cellular signaling involved in cell proliferation.... 2019-04-29 07:40:55 [Kojima, T., Funato, Y., Miki,]
1210 Multi-functional regulator MapZ controls both positioning and timing of FtsZ polymerization

DOI: 10.1042/BCJ20190138, The tubulin-like GTPase protein FtsZ, which forms a discontinuous cytokinetic ring at mid-cell, is a central player to recruit the division machinery to orchestrate cell division. To guarantee the production of two identical daughter cells, the assembly of FtsZ, namely Z-ri... 2019-04-29 07:40:55 [Feng, Z., Zhang, J., Xu, D., J]

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