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Total posts:1,207, Original posts:1,207, Reply posts:0

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Total posts: 1,207

1207 Starvation-induced autophagy is upregulated via ROS-mediated ClC-3 chloride channel activation in the nasopharyngeal car...

DOI: 10.1042/BCJ20180979, Nutrient deficiency develops frequently in nasopharyngeal carcinoma cell (CNE-2Z) due to the characteristics of aggregation and uncontrolled proliferation. Therefore, starvation can induce autophagy in these cells. Chloride channel3 (ClC-3), a member of the chloride channel... 2019-04-16 04:21:10 [Zheng, Y., Chen, Z., Gu, Z., Y]
1206 CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently prod...

DOI: 10.1042/BCJ20190202, Poxviruses encode many proteins that enable them to evade host anti-viral defense mechanisms. Spi-2 proteins, including Cowpox virus CrmA, suppress anti-viral immune responses and contribute to poxviral pathogenesis and lethality. These proteins are "serpin" proteas... 2019-04-16 04:21:10 [Bloomer, D. T., Kitevska-Ilios]
1205 PAS domain containing phosphoglycerate kinase deficiency in Leishmania major results in increased autophagosome formatio...

DOI: 10.1042/BCJ20190041, Per-Arnt-Sim (PAS) domains are structurally conserved and present in numerous proteins throughout all branches of the phylogenetic tree. Although PAS domain containing proteins are major players for the adaptation to environmental stimuli in both prokaryotic and eukaryotic ... 2019-04-15 04:32:03 [Adhikari, A., Biswas, S., Mukh]
1204 Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vac...

DOI: 10.1042/BCJ20180933, Communications between various organelle-organelles play an essential role in cell survival. The cross-talk between mitochondria and vacuoles come up with the vital roles of the intercompartmental process. In this study, we found a couple of cell death features, membrane da... 2019-04-08 08:43:03 [Lee, H., Hwang, J. S., Lee, D.]
1203 Novel Long-chain Neurotoxins from Bungarus candidus Distinguish the Two Binding Sites in Muscle-type Nicotinic Acetylcho...

DOI: 10.1042/BCJ20180909, α-Bungarotoxins, a novel group of long-chain α-neurotoxins, manifest different affinity to two agonist/competitive antagonist binding sites of muscle-type nicotinic acetylcholine receptors, being more active at the interface of α--subunits. Three isoforms (α-BgTx-1-3)... 2019-04-03 09:16:59 [Utkin, Y. N., Kuch, U., Kashev]
1202 Regulation of differential proton-coupled folate transporter gene expression in human tumors: Transactivation by KLF15 w...

DOI: 10.1042/BCJ20180394, Tumors can be therapeutically targeted with novel antifolates (e.g., AGF94) that are selectively transported by the human proton-coupled folate transporter (hPCFT). Studies were performed to determine the transcription regulation of hPCFT in tumors and identify possible mec... 2019-03-26 05:16:48 [Hou, Z., O'Connor, C., Fru]
1201 Calcium-Calmodulin Gating of a pH-insensitive isoform of Connexin43 Gap Junctions

DOI: 10.1042/BCJ20180912, Intracellular protons and calcium ions are two major chemical factors that regulate connexin43 (Cx43) gap junction communication and the synergism or antagonism between pH and Ca2+ has been questioned for decades. To assess the ability of Ca2+ ions to modulate Cx43 junction... 2019-03-25 07:09:52 [Wei, S., Cassara, C., Lin, X.,]
1200 Molecular Dynamics of C99-Bound {gamma}-Secretase Reveal Two Binding Modes with Distinct Compactness, Stability, and Act...

DOI: 10.1042/BCJ20190023, The membrane protease -secretase cleaves the C99 fragment of the amyloid precursor protein (APP) thus producing the Aβ peptides central to Alzheimer's disease. Cryo-electron microscopy has provided the topology but misses the membrane and loop parts that contribute t... 2019-03-25 07:09:52 [Dehury, B., Tang, N., Kepp, K.]
1199 Investigating the active site of human trimethyllysine hydroxylase

DOI: 10.1042/BCJ20180857, The biologically important carnitine biosynthesis pathway in humans proceeds via four enzymatic steps. The first step in carnitine biosynthesis is catalyzed by trimethyllysine hydroxylase (TMLH), a non-heme Fe(II) and 2-oxoglutarate (2OG) dependent oxygenase, which catalyze... 2019-03-21 04:28:08 [Wang, Y., Reddy, Y. V., Al Tem]
1198 Preferential adsorption to air-water interfaces: a novel cryoprotective mechanism for LEA proteins

DOI: 10.1042/BCJ20180901, Late embryogenesis abundant (LEA) proteins comprise a diverse family whose members play a key role in abiotic stress tolerance. As intrinsically disordered proteins, LEA proteins are highly hydrophilic and inherently stress tolerant. They have been shown to stabilize multip... 2019-03-21 04:28:08 [Yuen, F., Watson, M., Barker,]
1197 Glycolytic flux in Saccharomyces cerevisiae is dependent on RNA polymerase III and its negative regulator Maf1

DOI: 10.1042/BCJ20180701, Protein biosynthesis is energetically costly, is tightly regulated and is coupled to stress conditions including glucose deprivation. RNA polymerase III (RNAP III) driven transcription of tDNA genes for production of tRNAs is a key element in efficient protein biosynthesis.... 2019-03-18 06:10:56 [Szatkowska, R., Garcia-Alborno]
1196 Crystal structure of dimeric Synechococcus Spermidine Synthase with bound polyamine substrate and product

DOI: 10.1042/BCJ20180811, Spermidine is a ubiquitious polyamine synthesised by spermidine synthase (SPDS) from the substrates putrescine and decarboxylated S-adenosylmethionine (dcAdoMet). SPDS generally is active as homodimer but higher oligomerization states have been reported in SPDS from thermop... 2019-03-15 03:55:42 [Guedez, G., Pothipongsa, A., S]
1195 ADS-J1 Disaggregates Semen-derived Amyloid Fibrils

DOI: 10.1042/BCJ20180886, Semen-derived amyloid fibrils, composing SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, could remarkably enhance HIV-1 sexual transmission and thus, are potential targets for the development of an effective microbicide. Previously, we found that ... 2019-03-15 03:55:42 [Li, J., Yang, Z., Liu, H., Qiu]
1194 Plant glutathione biosynthesis revisited: Redox-mediated activation of glutamylcysteine ligase does not require homo-dim...

DOI: 10.1042/BCJ20190072, Plant -glutamylcysteine ligase (GCL), catalyzing the first and tightly regulated step of glutathione biosynthesis, is redox-activated via formation of an intramolecular disulfide bond. In vitro , redox-activation of recombinant GCL protein causes formation of homo-dimers. H... 2019-03-15 03:55:42 [Yang, Y., Lenherr, E., Gromes,]
1193 Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in...

DOI: 10.1042/BCJ20180867, The group A p21-activated kinases (PAKs) exist in an auto-inhibited form until activated by GTPase binding and auto-phosphorylation. In the auto-inhibited form a regulatory domain binds to the kinase domain blocking the binding of substrates, and CDC42 or Rac binding to the... 2019-03-11 05:56:00 [Sorrell, F. J., Kilian, L. M.,]
1192 Structure of SPH (Self-Incompatibility Protein Homologue) proteins, a widespread family of small, highly stable, secrete...

DOI: 10.1042/BCJ20180828, SPH proteins are a large family of small, disulphide-bonded, secreted proteins, initially found in the self-incompatibility response in the field poppy (Papaver rhoeas) , but now known to be widely distributed in plants, many containing multiple members of this protein fami... 2019-03-06 03:35:51 [Rajasekar, K., Ji, S., Coultha]
1191 Proline Residues in Scavenger Receptor-BI's C-terminal Region Support Efficient Cholesterol Transport

DOI: 10.1042/BCJ20180831, High density lipoproteins (HDL) facilitate reverse cholesterol transport, a process in which HDL removes cholesterol from circulation and carries it to the liver for biliary excretion. Reverse cholesterol transport is also facilitated by HDL's high-affinity receptor, sc... 2019-03-05 08:39:31 [Proudfoot, S. C., Sahoo, D.]
1190 Discovery of Natural Product Ovalicin Sensitive Type 1 Methionine Aminopeptidases: Molecular and Structural Basis

DOI: 10.1042/BCJ20180874, Natural product ovalicin and its synthetic derivative TNP-470 have been extensively studied for their anti-angiogenic property, and the later reached phase 3 clinical trials. They covalently modify the conserved histidine in Type 2 methionine aminopeptidases (MetAPs) at nan... 2019-03-05 03:52:53 [Pillalamarri, V., Arya, T., Ha]
1189 Conservation of the structural and functional architecture of encapsulated ferritins in bacteria and archaea

DOI: 10.1042/BCJ20180922, Ferritins are a large family of intracellular proteins that protect the cell from oxidative stress by catalytically converting Fe(II) into less toxic Fe(III) and storing iron minerals within their core. Encapsulated ferritins (EncFtn) are a sub-family of ferritin-like prote... 2019-03-05 03:52:53 [He, D., Piergentili, C., Ross,]
1188 Abscisic acid-determined seed vigour differences do not influence redox regulation during ageing

DOI: 10.1042/BCJ20180903, High seed quality is a key trait to achieve successful crop establishment required for optimum yield and sustainable production. Seed storage conditions greatly impact on two key seed quality traits; seed viability (ability to germinate and produce normal seedlings) and vig... 2019-02-28 04:27:47 [Schausberger, C., Roach, T., S]
1187 Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic {beta}-cells from huma...

DOI: 10.1042/BCJ20180820, The human islet amyloid polypeptide (hIAPP) or amylin is the major constituent of amyloidogenic aggregates found in pancreatic islets of type 2 diabetic patients that have been associated with b-cell dysfunction and/or death associated with type 2 diabetes mellitus (T2DM). ... 2019-02-27 04:52:16 [Dubey, R., Patil, K., Dantu, S]
1186 ParA proteins of secondary genome elements crosstalk and regulate radioresistance through genome copy number reduction i...

DOI: 10.1042/BCJ20180799, Deinococcus radiodurans, an extremely radioresistant bacterium has multipartite genome system and ploidy. Mechanisms underlying such types of bacterial genome maintenance and its role in extraordinary radioresistance are not known in this bacterium. Chromosome I (Chr I), ch... 2019-02-25 04:23:45 [Maurya, G. K., Kota, S., Kumar]
1185 Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of...

DOI: 10.1042/BCJ20180832, To closely mimic physiological conditions, low-oxygen cultures have been employed in stem cell and cancer research. Although in vivo oxygen concentrations in tissues are often much lower than ambient 21% O2 (ranging from 3.6 to 12.8% O2), most cell cultures are maintained a... 2019-02-20 03:34:52 [Sato, E., Maeda, Y., Sato, Y.,]
1184 Structure of SPH (Self-Incompatibility Protein Homologue) proteins, a widespread family of small, highly stable, secrete...

DOI: 10.1042/BCJ20180828, SPH proteins are a large family of small, disulphide-bonded, secreted proteins, initially found in the self-incompatibility response in the field poppy (Papaver rhoeas) , but now known to be widely distributed in plants, many containing multiple members of this protein fami... 2019-02-19 03:32:11 [Rajasekar, K., Ji, S., Coultha]
1183 Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seeds

DOI: 10.1042/BCJ20180911, Seed quality is affected by different constituents of the seed. In general, seed lots are considered to be of high quality when they exhibit fast and homogeneous germination. When seeds are stored they undergo different degrees of damage that have detrimental effects on the... 2019-02-19 03:32:11 [Vinegra de la Torre, N., Kasch]
1182 Cysteine-rich granulin-3 rapidly promotes amyloid-{beta} fibrils in both redox states.

DOI: 10.1042/BCJ20180916, Granulins (GRNs 1 - 7) are cysteine-rich proteolytic products of progranulin (PGRN) that have recently been implicated in neurodegenerative diseases including frontotemporal dementia (FTD) and Alzheimer disease (AD). Their precise mechanism in these pathologies remains unce... 2019-02-19 03:32:11 [Bhopatkar, A. A., Ghag, G., Wo]
1181 Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

DOI: 10.1042/BCJ20190038, Autophagy is essential for cellular homeostasis and when deregulated this survival mechanism has been associated with disease development. Inhibition of autophagy initiation by inhibiting the kinase ULK1 has been proposed as a potential cancer therapy. While inhibitors and ... 2019-02-19 03:32:11 [Chaikuad, A., Koschade, S. E.,]
1180 The lipid head group is the key element for substrate recognition by the P4 ATPase ALA2, a phosphatidylserine flippase

DOI: 10.1042/BCJ20180891, Type IV P-type ATPases (P4 ATPases) are lipid flippases that catalyze phospholipid transport from the exoplasmic to the cytoplasmic leaflet of cellular membranes, but the mechanism by which they recognize and transport phospholipids through the lipid bilayer remains unknown... 2019-02-12 04:37:30 [Theorin, L., Faxen, K., Sorens]
1179 Drosophila Hcf regulates Hippo signaling pathway via association with the histone H3K4 methyltransferase Trr

DOI: 10.1042/BCJ20180717, Control of organ size is a fundamental aspect in biology and plays important roles in development. The Hippo pathway is a conserved signaling cascade that controls tissue and organ size through the regulation of cell proliferation and apoptosis. Here, we report on the roles... 2019-02-07 07:13:29 [Nan, Z., Yang, W., Lyu, J., Wa]
1178 Substrate-assisted mechanism of catalytic hydrolysis of misaminoacylated tRNA required for protein synthesis fidelity

DOI: 10.1042/BCJ20180910, D-aminoacyl-tRNA-deacylase (DTD) prevents the incorporation of D-amino acids into proteins during translation by hydrolyzing the ester bond between mistakenly attached amino acids and tRNAs. Despite extensive study of this proofreading enzyme, the precise catalytic mechanis... 2019-02-04 01:23:21 [Ilchenko, M., Rybak, M., Rayev]

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