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Total posts:1,263, Original posts:1,263, Reply posts:0

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Total posts: 1,263

1263 Interactions between motor domains in kinesin-14 Ncd - a molecular dynamics study

DOI: 10.1042/BCJ20190484, Minus-end directed, non-processive kinesin-14 Ncd is a dimeric protein with C-terminally located motor domains (heads). Generation of the power-stroke by Ncd consists in a lever-like rotation of a long superhelical 'stalk' segment while one of the kinesin's head... 2019-08-15 03:44:21 [Ludwiczak, J., Szczęsna]
1262 The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methyl-malonyl-CoA

DOI: 10.1042/BCJ20190500, Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be promiscuous as it may use methylmalonyl-CoA instead of malonylCoA and thereby introduce methyl-branches. We have rec... 2019-08-15 03:44:21 [Dewulf, J. P., Gerin, I., Ride]
1261 A novel small molecule A2A receptor agonist, indirubin-3'-monoxime, alleviates lipid-induced inflammation and insuli...

DOI: 10.1042/BCJ20190251, Saturated free fatty acid induced adipocyte inflammation plays a pivotal role in implementing insulin resistance and type 2 diabetes. Recent reports suggest A2A adenosine receptor (A2AAR) could be an attractive choice to counteract adipocyte inflammation and insulin resista... 2019-08-13 06:19:42 [Choudhary, S. A., Bora, N., Ba]
1260 Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimul...

DOI: 10.1042/BCJ20190383, DHX8 is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the spliceosome. Here we report the biochemical characterization of full-length human DHX8 and the catalytically active helicase core DHX8547, alongside crystal str... 2019-08-13 06:19:42 [Felisberto-Rodrigues, C., Thom]
1259 Broken Force Dispersal Network in Tip-links by the Mutations at the Ca2+-binding Residues induces Hearing-Loss

DOI: 10.1042/BCJ20190453, Tip-link as force-sensor in hearing conveys the mechanical force originating from sound to ion-channels while maintaining the integrity of the entire sensory assembly in inner-ear. This delicate balance between structure and function of tip-links is regulated by Ca2+-ions p... 2019-08-09 08:06:19 [Hazra, J. P., Sagar, A., Arora]
1258 Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells

DOI: 10.1042/BCJ20190375, Hepsin is a transmembrane serine protease implicated in many biological processes, including hepatocyte growth, urinary protein secretion, auditory nerve development, and cancer metastasis. Zymogen activation is critical for hepsin function. To date, how hepsin is activated... 2019-08-08 03:54:44 [Wang, L., Zhang, C., Sun, S.,]
1257 The human transmembrane mucin MUC17 responds to TNF{alpha} by increased presentation at the plasma membrane

DOI: 10.1042/BCJ20190180, Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush border membrane of small intestinal enterocytes and presents an extended O -glycosylated mucin domain to the intestinal lumen. Here, we identified two unknown phosphorylated serine residu... 2019-08-06 03:35:17 [Schneider, H., Berger, E., Dol]
1256 Rhizobacteria AK1 remediates the toxic effects of salinity stress via regulation of endogenous phytohormones and gene ex...

DOI: 10.1042/BCJ20190435, Salinity stress adversely affects the growth and productivity of different crops. In the present study, we isolated the rhizospheric bacteria Arthrobacter woluwensis AK1 from Pohang beach, South Korea and determined its plant growth-promoting potential under NaCl salt stres... 2019-08-02 09:09:19 [Khan, M. A., Asaf, S., Khan, A]
1255 Crystal structures of plant inorganic pyrophosphatase, an enzyme with a moonlighting autoproteolytic activity

DOI: 10.1042/BCJ20190427, Inorganic pyrophosphatases (PPases, EC 3.6.1.1), which hydrolyze inorganic pyrophosphate to phosphate in the presence of divalent metal cations, play a key role in maintaining phosphorus homeostasis in cells. DNA coding inorganic pyrophosphatases from Arabidopsis thaliana (... 2019-08-01 03:26:05 [Grzechowiak, M., Ruszkowski, M]
1254 A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacterium

DOI: 10.1042/BCJ20190486, Aminoethylsulfonate (taurine) is widespread in the environment, and highly abundant in the human body. Taurine and other aliphatic sulfonates serve as sulfur sources for diverse aerobic bacteria, which carry out cleavage of the inert sulfonate C-S bond through various O2-de... 2019-07-26 06:56:12 [Xing, M., Wei, Y., Hua, G., Li]
1253 Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) modifies energy metabolism via 5' AMP-activated protein kinase...

DOI: 10.1042/BCJ20190121, Cancerous Inhibitor of protein phosphatase 2A (CIP2A) is an adverse biomarker across many malignancies. Using K562 cells engineered to have high or low CIP2A expression, we show that high CIP2A levels significantly bias cellular energy production towards oxidative phosphory... 2019-07-26 06:56:11 [Austin, J. A., Jenkins, R. E.,]
1252 ELP3 acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK)

DOI: 10.1042/BCJ20190106, Protein lysine acetylation is one of the major posttranslational modifications (PTMs) with several thousands of proteins identified to be acetylated in mammalian tissues. Mechanistic studies have revealed important functions of acetylation in the regulation of protein funct... 2019-07-24 04:18:48 [Li, M.-T., Liang, J.-Y., Sun,]
1251 Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies

DOI: 10.1042/BCJ20190207, Over the past two decades ribosome biogenesis has emerged as an attractive target for cancer treatment. In this study, two high-throughput screens were used to identify ribosome biogenesis inhibitors. Our primary screen made use of the HaloTag selective labeling strategy to... 2019-07-24 04:18:48 [Scull, C. E., Zhang, Y., Tower]
1250 Dissecting the cytochrome c2-reaction centre interaction in bacterial photosynthesis using single molecule force spectro...

DOI: 10.1042/BCJ20170519, The reversible docking of small, diffusible redox proteins onto a membrane protein complex is a common feature of bacterial, mitochondrial and photosynthetic electron transfer (ET) chains. Spectroscopic studies of ensembles of such redox partners have been used to determine... 2019-07-18 06:05:22 [Vasilev, C., Mayneord, G. E.,]
1249 A Biochemical Comparison of Fungal GH6 Cellobiohydrolases

DOI: 10.1042/BCJ20190185, Cellobiohydrolases (CBHs) from Glycoside Hydrolase Family 6 (GH6) make up an important part of the secretome in many cellulolytic fungi. They are also of technical interest, particularly because they are part of the enzyme cocktails that are used for industrial breakdown of... 2019-07-16 03:35:41 [Christensen, S. J., Krogh, K.]
1248 The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization

DOI: 10.1042/BCJ20180840, One hallmark of Alzheimer's disease (AD) is the presence of amyloid plaques, which mainly consist of the amyloid precursor protein (APP) cleavage product amyloid β (Aβ). For cleavage to occur, APP must be endocytosed from the cell surface. The phosphatidylinositol bi... 2019-07-12 04:29:58 [Merthan, L., Haller, A., Thal,]
1247 Simple rules govern the diversity of bacterial nicotianamine-like metallophores

DOI: 10.1042/BCJ20190384, In metal-scarce environments, some pathogenic bacteria produce opine-type metallophores mainly to face the host's nutritional immunity. This is the case of staphylopine, pseudopaline and yersinopine, identified in Staphylococcus aureus , Pseudomonas aeruginosa and Yersi... 2019-07-12 04:00:31 [Laffont, C., Brutesco, C., Haj]
1246 Structural insights into SUMO E1-E2 interactions in Arabidopsis uncovers a distinctive platform for securing SUMO conjug...

DOI: 10.1042/BCJ20190232, SUMOylation of proteins involves the concerted action of the E1-activating enzyme, E2-conjugating enzyme and E3-ligases. An essential discrimination step in the SUMOylation pathway corresponds to the initial interaction between E1 ubiquitin-fold domain (UFD) and E2 enzymes.... 2019-07-10 03:36:00 [Liu, B., Lois, L. M., Reverter]
1245 Sugar beet hemoglobins: reactions with nitric oxide and nitrite reveal differential roles for nitrogen metabolism

DOI: 10.1042/BCJ20190154, In contrast to human hemoglobin (Hb) in red blood cells, plant Hbs do not transport oxygen, instead research points towards nitrogen metabolism. Using comprehensive and integrated biophysical methods we characterized three sugar beet Hbs: BvHb1.1, BvHb1.2 and BvHb2. Their a... 2019-07-08 03:50:56 [Leiva Eriksson, N., Reeder, B.]
1244 Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity

DOI: 10.1042/BCJ20180382, Interleukin 2 (IL-2) is critical for T cell development and homeostasis, being a key regulator of adaptive immune responses in autoimmunity, hypersensitivity reactions and cancer. Therefore, its abundance in serum and peripheral tissues needs tight control. Here, we describ... 2019-07-01 07:56:32 [Rybakin, V., Stas, M., Ugarte-]
1243 Biochemical features of primary cells from a pediatric patient with a gain-of-function ODC1 genetic mutation

DOI: 10.1042/BCJ20190294, We recently described a new autosomal dominant genetic disorder in a pediatric patient caused by a heterozygous de novo mutation in the ornithine decarboxylase 1 ( ODC1 ) gene. The new genetic disorder is characterized by global developmental delay, alopecia, overgrowth, an... 2019-06-27 04:29:31 [Schultz, C. R., Bupp, C. P., R]
1242 Complementary substrate specificity and distinct quaternary assembly of the Escherichia coli aerobic and anaerobic beta-...

DOI: 10.1042/BCJ20190314, The trifunctional enzyme (TFE) catalyzes the last three steps of the fatty acid β-oxidation cycle. Two TFEs are present in Escherichia coli , EcTFE and anEcTFE. EcTFE is expressed only under aerobic conditions whereas anEcTFE is expressed also under anaerobic conditions,... 2019-06-25 03:29:23 [Sah-Teli, S. K., Hynonen, M. J]
1241 Complementary substrate specificity and distinct quaternary assembly of the Escherichia coli aerobic and anaerobic beta-...

DOI: 10.1042/BCJ20190314, The trifunctional enzyme (TFE) catalyzes the last three steps of the fatty acid β-oxidation cycle. Two TFEs are present in Escherichia coli , EcTFE and anEcTFE. EcTFE is expressed only under aerobic conditions whereas anEcTFE is expressed also under anaerobic conditions,... 2019-06-24 09:39:30 [Sah-Teli, S. K., Hynonen, M. J]
1240 Metabolic remodeling of cardiomyocyte identified in phosphoinositide-dependent kinase 1-deficient mice

DOI: 10.1042/BCJ20190105, Metabolic remodeling plays an essential role in the pathophysiology of heart failure. Many studies have shown that disruption of phosphoinositide-dependent protein kinase-1 (PDK1) caused severe and lethal heart failure, however, the metabolic pattern of PDK1 deletion remain... 2019-06-17 08:54:30 [Li, C., Niu, Y., Zheng, H., Sh]
1239 Nitration-Induced Ubiquitination and Degradation Control Quality of ERK1

DOI: 10.1042/BCJ20190240, The mitogen-activated protein kinase ERK1/2 (ERKs) play important roles in a wide spectrum of cellular processes and have been implicated in a number of disease states. The spatiotemporal regulation of ERKs activity has been extensively studied. However, scarce information ... 2019-06-13 03:29:12 [Zhang, Y., Huang, X., Wang, J.]
1238 DEK Terminates Diapause by Activation of Quiescent Cells in the Crustacean Artemia

DOI: 10.1042/BCJ20190169, To cope with harsh environments the Artemia shrimp produces gastrula embryos in diapause, a state of obligate dormancy, having cellular quiescence and suppressed metabolism. The mechanism behind these cellular events remains largely unknown. Here, we study the regulation of... 2019-06-12 07:58:10 [Jia, W.-H., Li, A.-Q., Feng, J]
1237 AMP-activated protein kinase complexes containing the {beta}2 regulatory subunit are upregulated during and contribute t...

DOI: 10.1042/BCJ20180714, AMP-activated protein kinase (AMPK) is a heterotrimer of α catalytic and β and regulatory subunits that acts to regulate cellular and whole-body nutrient metabolism. The key role of AMPK in sensing energy status has led to significant interest in AMPK as a therapeutic ta... 2019-06-12 04:36:54 [Katwan, O. J., Alghamdi, F., A]
1236 The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: Redox as an upstream...

DOI: 10.1042/BCJ20190077, Calcium signaling is essential for embryonic development but the signals upstream of calcium are only partially understood. Here we investigate the role of the intracellular glutathione redox potential in calcium signaling using the Chac1 protein of zebrafish. A member of t... 2019-06-12 04:36:53 [Yadav, S., Chawla, B., Khurshe]
1235 Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors wit...

DOI: 10.1042/BCJ20190288, Strigolactones are multifunctional plant hormones regulating essential physiological processes affecting growth and development. In vascular plants, strigolactones are recognized by α/β hydrolase fold proteins from the D14/DAD2 family in the initial step of the signallin... 2019-06-11 03:58:42 [Hamiaux, C., Larsen, L., Lee,]
1234 Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in ...

DOI: 10.1042/BCJ20190336, Thiol-based redox regulation is crucial for adjusting chloroplast functions under fluctuating light environments. We recently discovered that the thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP) redox cascade supports oxidative thiol modulation by using hydrogen peroxide... 2019-06-06 04:53:38 [Yoshida, K., Uchikoshi, E., Ha]

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